Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats

Gołyński Marcin; Metyk Michał; Szkodziak Piotr; Lutnicki Krzysztof; Kalisz Grzegorz; Szczepanik Marcin; Wilkołek Piotr; Dobrowolski Piotr

doi:10.2478/jvetres-2019-0008

Journal of Veterinary Research (Mar 2019)

Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats

Gołyński Marcin,
Metyk Michał,
Szkodziak Piotr,
Lutnicki Krzysztof,
Kalisz Grzegorz,
Szczepanik Marcin,
Wilkołek Piotr,
Dobrowolski Piotr

Affiliations

Gołyński Marcin: Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland
Metyk Michał: Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland
Szkodziak Piotr: 3rd Chair and Department of Gynecology, Medical University of Lublin, 20-954Lublin, Poland
Lutnicki Krzysztof: Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland
Kalisz Grzegorz: Department of Biopharmacy, Chair of Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 20-093Lublin, Poland
Szczepanik Marcin: Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland
Wilkołek Piotr: Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland
Dobrowolski Piotr: Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, 20-033Lublin, Poland

DOI: https://doi.org/10.2478/jvetres-2019-0008
Journal volume & issue: Vol. 63, no. 1
pp. 161 – 166

Abstract

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Introduction: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known.

Published in Journal of Veterinary Research

ISSN: 2450-8608 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://sciendo.com/journal/JVETRES

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