Study of antiatherogenic effects of simvaglyzin on rabbit’s hypercholesterolemia model

Abstract

In cholesterol-fed rabbits with hypercholesterolemia it was revealed that complex of simvastatin (SV) with glycyrrhizic acid (1–4), simvaglyzin (SVG) had reduced effect on total blood cholesterol (CH) in appropriated equiponderant doses of SV 40, 66,5 and 100 mkg/kg/per day that was equal to such effect of SV 200 mkg/kg/per day. The decrease in total blood CH was 39, 36, 47 и 38 %, respectively, compared to control group after 20 day of drugs administration. Myopathic effect of SVG, evaluated by the blood activity of creatine kinase, was 26, 24 and 29 % lower in stated 3 doses of SVG, respectively, compared to SV dose after 30 day of drugs administration. Also, SVG had antioxidative effect result from reducing of blood lipid peroxidation level on 27–41 % and normalizing endothelium function effect result from reducing of blood levels of von Willebrand factor and endothelin-1 on 26–58 % and 21–29 %, respectively, in appropriated equiponderant doses of SVG 66,6 and 40 mkg/kg/per day that was equal to such effect of SV 200 mkg/kg/per day.

Keywords

• simvaglyzin
• simvastatin
• hypercholesterolemia in rabbits
• lipid profile
• hepatic enzymes
• antioxidant effect
• endothelial dysfunction