Zhongguo quanke yixue (Oct 2023)
Clinical Study on the Combination of Xiaotan Huayu Tongyi Granules, Channel Kaijie Pills and Chemotherapy in the Treatment of Esophageal Cancer
Abstract
Background Esophageal cancer threatens the life and health of patients due to its complex etiology and poor prognosis, and individualized combination treatment of traditional Chinese medicine and western medicine has certain advantages. Objective To observe the clinical efficacy of the combination of Xiaotan Huayu Tongyi Granules, Channel Kaijie Pills and CF regimen (fluorouracil+cisplatin) on the treatment of stage Ⅲ-Ⅳ phlegm-stasis interjunction esophageal squamous cell carcinoma. Methods A total of 99 patients with phlegm-stasis interjunction type esophageal squamous cell carcinoma diagnosed and treated in Henan Hospital of Traditional Chinese Medicine, Anyang Cancer Hospital and Henan Cancer Hospital from February 2020 to February 2021 were selected as the study objects and randomly divided into the control group, treatment groupⅠand treatment groupⅡ, with 33 cases in each group. The control group was treated with CF regimen, the treatment groupⅠwas treated with Xiaotan Huayu Tongyi Granules combined with CF regimen, and the treatment groupⅡ was treated with the combination of Xiaotan Huayu Tongyi Granules, Channel Kaijie Pills and CF regimen. A total of 4 courses of chemotherapy were administered with 21 days as a course. The differences in TCM syndrome score, quality of life score, Karnofsky Performance Status (KPS) score, lesion remission rate, carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and toxic side effects among the three groups were observed. Results There was no significant difference in gender, age, body mass and tumor staging among the three groups (P>0.05). Compared with pre-treatment, retrosternal chest pain, nausea and vomiting, mucus and vomit, vomitus scores and total score were reduced in the three groups, dysphagia, oligophagia and dry stool scores were reduced in the control group and treatment group Ⅱafter treatment (P<0.05) ; quality of life score and KPS score were increased, CEA and SCC levels were reduced in the three groups after treatment (P<0.05). After treatment, dysphagia, retrosternal chest pain, nausea and vomiting, vomitus, oligophagia, dry stool scores and total score in treatment groupⅡwere lower than the control group and treatment groupⅠ, and mucus and vomit score was lower than the control group (P<0.05) ; quality of life score and KPS score in both treatment groups were higher than the control group, KPS score in the treatment groupⅡwas higher than the treatment groupⅠ, CEA and SCC levels in the treatment groupⅡwere lower than the treatment groupⅠand control group (P<0.05). There was no statistically significant difference in the lesion remission rate and toxic side effects among the three groups after treatment (P>0.05) . Conclusion The combination of Xiaotan Huayu Tongyi Granules, Channel Kaijie Pills and CF regimen in the treatment of stageⅢ-Ⅳphlegm-stasis interjunction esophageal squamous cell carcinoma can improve clinical symptoms, reduce the levels of tumor markers, and improve the quality of life of patients.
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