Anti-inflammatory and antioxidant feeding and supplementation may serve as adjuvants in women with fibromyalgia

Abstract

Objectives: Fibromyalgia syndrome is a chronic pain disorder of unknown causation associated with debilitating fatigue, unrefreshing sleep, cognitive and affective symptoms. There are no markers to monitor fibromyalgia progression and no cure. We aimed to analyze the effects of a turmeric-based supplement and a gluten-free, fermentable oligosaccharides, disaccharides, monosaccharides, and polyols and low histamine diet (IGUBAC Diet®), with antioxidant and anti-inflammatory characteristics, in women with fibromyalgia. Methods: a randomized, controlled, clinical trial, with 13 women (51.46 ± 8.04 years) diagnosed with fibromyalgia were assessed using the Chronic Pain Grade Scale, the Pain Catastrophizing Scale, the Fatigue Severity and Impact Scale and the Pittsburgh Sleep Quality Index. Anthropometric parameters, antioxidant and anti-inflammatory analysis and symptoms progression were measured before and after one month of treatment with turmeric supplement and IGUBAC Diet®. Results: No significant improvement was observed after one month of treatment as shown by Chronic Pain Grade-, Pain Catastrophizing-, Fatigue Severity- and Fatigue Impact Scales and Pittsburgh Sleep Quality Index, except for pain disturbances in work activities. Significant variations (p < 0.05) were observed in the intensity of symptoms, except for nausea and vomiting. Conclusion: Additional research is necessary to further elucidate the effects of a turmeric-based supplement with IGUBAC Diet® in women with fibromyalgia. A multidisciplinary approach should be the goal of treatment for fibromyalgia. Keywords: Anti-inflammatory, Antioxidant, Fibromyalgia, Supplementation, Turmeric