Nature Communications (Aug 2020)

Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn’s disease

  • Xu Zhang,
  • Zhibin Ning,
  • Janice Mayne,
  • Yidai Yang,
  • Shelley A. Deeke,
  • Krystal Walker,
  • Charles L. Farnsworth,
  • Matthew P. Stokes,
  • Jean-François Couture,
  • David Mack,
  • Alain Stintzi,
  • Daniel Figeys

DOI
https://doi.org/10.1038/s41467-020-17916-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Intestinal microbiota is increasingly reported to influence human health, but little is known on how its functions are regulated. Here the authors characterize microbiome protein acetylation and demonstrate its potential roles in shaping gut microbial functions and the onset of Crohn’s disease.