Nature Communications (Feb 2016)

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

  • Jinjin Xu,
  • Lei Zhou,
  • Lei Ji,
  • Fengyuan Chen,
  • Karen Fortmann,
  • Kun Zhang,
  • Qingwu Liu,
  • Ke Li,
  • Weicang Wang,
  • Hao Wang,
  • Wei Xie,
  • Qingwei Wang,
  • Jiang Liu,
  • Biao Zheng,
  • Pei Zhang,
  • Shixia Huang,
  • Tieliu Shi,
  • Biaohong Zhang,
  • Yongyan Dang,
  • Jiwu Chen,
  • Bert W. O’Malley,
  • Robb E. Moses,
  • Ping Wang,
  • Lei Li,
  • Jianru Xiao,
  • Alexander Hoffmann,
  • Xiaotao Li

DOI
https://doi.org/10.1038/ncomms10761
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.