Nature Communications (Nov 2021)

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

  • Nathan Riguet,
  • Anne-Laure Mahul-Mellier,
  • Niran Maharjan,
  • Johannes Burtscher,
  • Marie Croisier,
  • Graham Knott,
  • Janna Hastings,
  • Alice Patin,
  • Veronika Reiterer,
  • Hesso Farhan,
  • Sergey Nasarov,
  • Hilal A. Lashuel

DOI
https://doi.org/10.1038/s41467-021-26684-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 27

Abstract

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The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert their toxicity via different pathways.