Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes

Abstract

Anti-β2-glycoprotein I/HLA-DR (anti-β2GPI/HLA-DR) antibody has been reported to be associated with antiphospholipid syndrome and recurrent pregnancy loss (RPL). We conducted a prospective multicenter cross-sectional study aimed at evaluating whether the anti-β2GPI/HLA-DR antibody is associated with adverse obstetric outcomes and RPL. From 2019 to 2021, serum anti-β2GPI/HLA-DR antibody levels (normal, p p p < 0.01) although not for PD ≤ 34 GWs. For the first time, our study demonstrated that the anti-β2GPI/HLA-DR antibody is involved in the pathophysiology underlying FGR and HDP, as well as RPL.

Keywords

• antiphospholipid syndrome
• autoantibody
• β2-glycoprotein I
• fetal growth restriction
• HLA class II
• hypertensive disorders of pregnancy