Journal of Anesthesia, Analgesia and Critical Care (May 2022)

High rates of impaired quality of life and social and economic problems at 6 months after COVID-19-related ARDS

  • Michele Umbrello,
  • Sara Miori,
  • Andrea Sanna,
  • Sergio Lassola,
  • Elena Baruzzo,
  • Daniele Penzo,
  • Giovanni Pedrotti,
  • Annamaria Perino,
  • Angelo Colombo,
  • Rocco Pace,
  • Sandra Magnoni

DOI
https://doi.org/10.1186/s44158-022-00048-5
Journal volume & issue
Vol. 2, no. 1
pp. 1 – 15

Abstract

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Abstract Purpose Assess long-term quality of life (HR-QoL) and socio-economic impact in COVID-19-related ARDS (C-ARDS) survivors. Methods C-ARDS survivors were followed up at 6 months in this prospective, cohort study. HR-QoL was assessed using SF-36 and EQ-5D-5L, and the socio-economic burden of COVID-19 was evaluated with a dedicated questionnaire. Clinical data were prospectively recorded. Results Seventy-nine survivors, age 63 [57-71], 84% male, were enrolled. The frequency of EQ-5D-5L reported problems was significantly higher among survivors compared to normal, in mobility, usual activities, and self-care; anxiety and depression and pain were not different. SF-36 scores were lower than the reference population, and physical and mental summary scores were below normal in 52% and 33% of the subjects, respectively. In the multivariable analysis, prolonged hospital length of stay (OR 1.45; p 0.02) and two or more comorbidities on admission (OR 7.42; p 0.002) were significant predictors of impaired “physical” and “mental” HR-QoL, respectively. A total of 38% subjects worsened social relations, 42% changed their employment status, and 23% required personal care support. Conclusions C-ARDS survivors have long-term impairment in HR-QoL and socio-economic problems. Prolonged hospital stay and previous comorbidities are risk factors for developing health-related issues.

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