Synthesis, Characterization and Evaluation Antibacterial Activity of Some Schiff Bases and (1,3-Oxazepine or Diazepine-4,7-Dione)

Abstract

In this study, some of Schiff bases, 1,3-oxazepine-4,7-dione and 1,3-diazepine-4,7-dione compounds derived from terephthalaldehyde and substituted aniline have been prepared, Schiff bases (a1-5) which derived from terephthalaldehyde and substituted aniline have been reacted with maleic anhydride and phthalic anhydride to produce 1,3-oxazepine-4,7-dione compounds (b1-10). 1,3-oxazepine-4,7-dione compounds (b1-10) have been reacted with phenyl hydrazine to produce 1,3-diazepine-4,7-dione compounds (c1-10). The prepared compounds were characterized using physical methods, the precise analysis of elements (C.H.N), infrared (IR) and (1H NMR) spectroscopy. The reactions were monitored by. Thin Layer Chromatography (TLC). The antibacterial activity was evaluated for some of the synthesis compounds.ً.

Keywords

• schiff bases
• oxazepine
• diazepine