Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

Hanjing Yang; Fumiaki Ito; Aaron D. Wolfe; Shuxing Li; Nazanin Mohammadzadeh; Robin P. Love; Maocai Yan; Brett Zirkle; Amit Gaba; Linda Chelico; Xiaojiang S. Chen

doi:10.1038/s41467-020-14377-y

Nature Communications (Jan 2020)

Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

Hanjing Yang,
Fumiaki Ito,
Aaron D. Wolfe,
Shuxing Li,
Nazanin Mohammadzadeh,
Robin P. Love,
Maocai Yan,
Brett Zirkle,
Amit Gaba,
Linda Chelico,
Xiaojiang S. Chen

Affiliations

Hanjing Yang: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Fumiaki Ito: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Aaron D. Wolfe: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Shuxing Li: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Nazanin Mohammadzadeh: Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan
Robin P. Love: Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan
Maocai Yan: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Brett Zirkle: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California
Amit Gaba: Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan
Linda Chelico: Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan
Xiaojiang S. Chen: Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California

DOI: https://doi.org/10.1038/s41467-020-14377-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into domain organization, multimerization, RNA binding, and viral restriction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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