Frontiers in Genetics (May 2022)
Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma
- Kaixin Su,
- Kaixin Su,
- Kaixin Su,
- Kaixin Su,
- Kaixin Su,
- Kaixin Su,
- Zekun Zhou,
- Zekun Zhou,
- Zekun Zhou,
- Zekun Zhou,
- Zekun Zhou,
- Zekun Zhou,
- Qiao Yi,
- Qiao Yi,
- Qiao Yi,
- Qiao Yi,
- Qiao Yi,
- Qiao Yi,
- Junjie Liu,
- Junjie Liu,
- Junjie Liu,
- Junjie Liu,
- Junjie Liu,
- Junjie Liu,
- Tiao Luo,
- Tiao Luo,
- Tiao Luo,
- Tiao Luo,
- Tiao Luo,
- Tiao Luo,
- Xinyan Cui,
- Xinyan Cui,
- Xinyan Cui,
- Xinyan Cui,
- Xinyan Cui,
- Xinyan Cui,
- Haixia Zhang
Affiliations
- Kaixin Su
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Kaixin Su
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Kaixin Su
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Kaixin Su
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Kaixin Su
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Kaixin Su
- Xiangya School of Stomatology, Central South University, Changsha, China
- Zekun Zhou
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Zekun Zhou
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Zekun Zhou
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Zekun Zhou
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Zekun Zhou
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Zekun Zhou
- Xiangya School of Stomatology, Central South University, Changsha, China
- Qiao Yi
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Qiao Yi
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Qiao Yi
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Qiao Yi
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Qiao Yi
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Qiao Yi
- Xiangya School of Stomatology, Central South University, Changsha, China
- Junjie Liu
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Junjie Liu
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Junjie Liu
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Junjie Liu
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Junjie Liu
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Junjie Liu
- Xiangya School of Stomatology, Central South University, Changsha, China
- Tiao Luo
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Tiao Luo
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Tiao Luo
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Tiao Luo
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Tiao Luo
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Tiao Luo
- Xiangya School of Stomatology, Central South University, Changsha, China
- Xinyan Cui
- Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, China
- Xinyan Cui
- Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, China
- Xinyan Cui
- Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, China
- Xinyan Cui
- Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, China
- Xinyan Cui
- Xiangya Stomatological Hospital, Central South University, Changsha, China
- Xinyan Cui
- Xiangya School of Stomatology, Central South University, Changsha, China
- Haixia Zhang
- The Oncology Department of Xiangya Second Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fgene.2022.860712
- Journal volume & issue
-
Vol. 13
Abstract
Background: Head and neck squamous cell carcinoma’s tumor immune microenvironment (TIME) plays an important role in tumorigenesis and progression, but its clinical significance remains unclear. Therefore, the TIME needs to be better understood in order to improve the response of diagnosis and therapy.Methods: The gene expression and clinical data of 569 HNSCC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). Immune-related genes (IRGs) from the ImmPort database were used for immunotyping of HNSCC patients, and independent GEO datasets were used for subtype verification and comprehensive molecular identification.Results: The patients were divided into three subtypes (C1, C2, and C3) related to different gene expression profiles. The three subtypes showed widely different patterns in tumor genetic distortion, immune cell composition, cytokine profile, and so on, verifying that the immune-enhanced C2 subtype was associated with better prognosis. In addition, the stroma-deficient C1 subtype may be more efficient for the immune response than the C3 subtype. Furthermore, using WGCNA on the IRGs of those three subtypes, we found two C2-positive gene modules closely related to infection- and immune-associated pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, and the two modules had 22 common pathways.Conclusion: This study improves the power for prognosis prediction and develops new therapeutic strategies to stratify HNSCC patients into clinically significant groups through TIME-related prognostic signature.
Keywords
- bioinformatics
- immune microenvironment
- prognosis
- clinically significant groups
- head and neck squamous cell carcinoma