Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Eunhee Choi; Sotaro Kikuchi; Haishan Gao; Karolina Brodzik; Ibrahim Nassour; Adam Yopp; Amit G. Singal; Hao Zhu; Hongtao Yu

doi:10.1038/s41467-019-09318-3

Nature Communications (Apr 2019)

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Eunhee Choi,
Sotaro Kikuchi,
Haishan Gao,
Karolina Brodzik,
Ibrahim Nassour,
Adam Yopp,
Amit G. Singal,
Hao Zhu,
Hongtao Yu

Affiliations

Eunhee Choi: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center
Sotaro Kikuchi: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center
Haishan Gao: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center
Karolina Brodzik: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center
Ibrahim Nassour: Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Adam Yopp: Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Amit G. Singal: Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Hao Zhu: Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
Hongtao Yu: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-019-09318-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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