Nature Communications (Oct 2018)
A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy
- Guocan Yu,
- Shan Yu,
- Manik Lal Saha,
- Jiong Zhou,
- Timothy R. Cook,
- Bryant C. Yung,
- Jin Chen,
- Zhengwei Mao,
- Fuwu Zhang,
- Zijian Zhou,
- Yijing Liu,
- Li Shao,
- Sheng Wang,
- Changyou Gao,
- Feihe Huang,
- Peter J. Stang,
- Xiaoyuan Chen
Affiliations
- Guocan Yu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Shan Yu
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Manik Lal Saha
- Department of Chemistry, University of Utah
- Jiong Zhou
- State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance and Novel Materials, Department of Chemistry, Zhejiang University
- Timothy R. Cook
- Department of Chemistry, University at Buffalo, State University of New York
- Bryant C. Yung
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Jin Chen
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Zhengwei Mao
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Fuwu Zhang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Zijian Zhou
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Yijing Liu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Li Shao
- State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance and Novel Materials, Department of Chemistry, Zhejiang University
- Sheng Wang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Changyou Gao
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
- Feihe Huang
- State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance and Novel Materials, Department of Chemistry, Zhejiang University
- Peter J. Stang
- Department of Chemistry, University of Utah
- Xiaoyuan Chen
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-06574-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
It is challenging to design photosensitizers (PS) with high quantum yields generating singlet oxygen due to severe aggregation between the hydrophobic PSs. Here they develop organoplatinum(II) metallatocage-based PS to overcome these challenges and show excellent antitumor effect.
