Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Mohammed Soutto; Zheng Chen; Ajaz A. Bhat; Lihong Wang; Shoumin Zhu; Ahmed Gomaa; Andreia Bates; Nadeem S. Bhat; Dunfa Peng; Abbes Belkhiri; M. Blanca Piazuelo; M. Kay Washington; Xi Chen Steven; Richard Peek; Wael El-Rifai

doi:10.1038/s41467-019-11011-4

Nature Communications (Jul 2019)

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Mohammed Soutto,
Zheng Chen,
Ajaz A. Bhat,
Lihong Wang,
Shoumin Zhu,
Ahmed Gomaa,
Andreia Bates,
Nadeem S. Bhat,
Dunfa Peng,
Abbes Belkhiri,
M. Blanca Piazuelo,
M. Kay Washington,
Xi Chen Steven,
Richard Peek,
Wael El-Rifai

Affiliations

Mohammed Soutto: Department of Veterans Affairs, Miami Healthcare System
Zheng Chen: Department of Veterans Affairs, Miami Healthcare System
Ajaz A. Bhat: Department of Surgery, University of Miami Miller School of Medicine
Lihong Wang: Department of Surgery, Vanderbilt University Medical Center
Shoumin Zhu: Department of Surgery, University of Miami Miller School of Medicine
Ahmed Gomaa: Department of Surgery, University of Miami Miller School of Medicine
Andreia Bates: Department of Surgery, Vanderbilt University Medical Center
Nadeem S. Bhat: Department of Surgery, University of Miami Miller School of Medicine
Dunfa Peng: Department of Surgery, University of Miami Miller School of Medicine
Abbes Belkhiri: Department of Surgery, Vanderbilt University Medical Center
M. Blanca Piazuelo: Department of Medicine, Vanderbilt University Medical Center
M. Kay Washington: Department of Pathology, Vanderbilt University Medical Center
Xi Chen Steven: Department of Public Health Sciences, Division of Biostatistics, University of Miami Miller School of Medicine
Richard Peek: Department of Medicine, Vanderbilt University Medical Center
Wael El-Rifai: Department of Veterans Affairs, Miami Healthcare System

DOI: https://doi.org/10.1038/s41467-019-11011-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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