Fiyz̤ (Nov 2020)
The histomorphological effect of Viola odorata flower extract on skin wound healing process in Wistar rats
Abstract
Background: Wound healing is an important concern that humankind is facing and attempting to find compounds that have the least side effects on wound healing is important. Since violet flower extract has anti-inflammatory and disinfection effects, in this study the impact of this plant on wound healing was examined. Materials and Methods: 32 rats were provided from the laboratory animal breeding center in Shahrekord, and after anesthetizing them, a full-thickness skin wound was created by a 2 by 2 Cm stencil in the posterior cervical region. The control group received no treatment, one group received Eucerin, another group received Silver Sulfadiazine 1% and the experimental group received ointment of violet flower extract 20% twice a day. Throughout the study, the length and width of the wounds were measured in each group every three days. On the 3rd, 7th, 14th and 21st days after creating the wound, the rats were anesthetized and the healed tissues were examined for histopathologic studies. Results: The results showed a significant reduction in wound area in treated animals, especially violets, compared with the control group (P<0.05). Histopathologically, the thickness of the epithelium and the amount of collagen showed a significant increase in the experimental group of violets. Conclusion: This can probably be attributed to the anti-inflammatory effects of the effective components of violet flower. also it’s likely that these components stimulate collagen production and quicker contraction of wounds. Therefore, the compounds of this plant can be used to treat wounds.
