Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

Xin Wang; Ge Qin; Xiaoting Liang; Wen Wang; Zhuo Wang; Dan Liao; Li Zhong; Ruhua Zhang; Yi-Xin Zeng; Yuanzhong Wu; Tiebang Kang

doi:10.1038/s41467-020-14870-4

Nature Communications (Feb 2020)

Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

Xin Wang,
Ge Qin,
Xiaoting Liang,
Wen Wang,
Zhuo Wang,
Dan Liao,
Li Zhong,
Ruhua Zhang,
Yi-Xin Zeng,
Yuanzhong Wu,
Tiebang Kang

Affiliations

Xin Wang: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Ge Qin: The Sixth Affiliated Hospital, Sun Yat-sen University
Xiaoting Liang: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Wen Wang: Department of Abdominal Oncology, The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University
Zhuo Wang: Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University
Dan Liao: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Li Zhong: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Ruhua Zhang: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Yi-Xin Zeng: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Yuanzhong Wu: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Tiebang Kang: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center

DOI: https://doi.org/10.1038/s41467-020-14870-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

Osteosarcoma is an aggressive tumour and little is known the mechanisms underpinning its highly metastatic nature. Here, the authors highlight a role for the CK1α/CBX4 axis in driving metastasis, suggesting that this pathway might be targeted for therapeutic benefit.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal