Nature Communications (Dec 2017)
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut
- Andrea Romagnani,
- Valentina Vettore,
- Tanja Rezzonico-Jost,
- Sarah Hampe,
- Elsa Rottoli,
- Wiebke Nadolni,
- Michela Perotti,
- Melanie A. Meier,
- Constanze Hermanns,
- Sheila Geiger,
- Gunther Wennemuth,
- Camilla Recordati,
- Masayuki Matsushita,
- Susanne Muehlich,
- Michele Proietti,
- Vladimir Chubanov,
- Thomas Gudermann,
- Fabio Grassi,
- Susanna Zierler
Affiliations
- Andrea Romagnani
- Institute for Research in Biomedicine, Università della Svizzera Italiana
- Valentina Vettore
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Tanja Rezzonico-Jost
- Institute for Research in Biomedicine, Università della Svizzera Italiana
- Sarah Hampe
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Elsa Rottoli
- Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano
- Wiebke Nadolni
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Michela Perotti
- Institute for Research in Biomedicine, Università della Svizzera Italiana
- Melanie A. Meier
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Constanze Hermanns
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Sheila Geiger
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Gunther Wennemuth
- Institute for Anatomy, Universitätsklinikum Essen
- Camilla Recordati
- Filarete Foundation
- Masayuki Matsushita
- Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus
- Susanne Muehlich
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Michele Proietti
- Institute for Research in Biomedicine, Università della Svizzera Italiana
- Vladimir Chubanov
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Thomas Gudermann
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- Fabio Grassi
- Institute for Research in Biomedicine, Università della Svizzera Italiana
- Susanna Zierler
- Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München
- DOI
- https://doi.org/10.1038/s41467-017-01960-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells
