BMC Cancer (Feb 2023)
Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition
- S. G. Yammine,
- I. Huybrechts,
- C. Biessy,
- L. Dossus,
- S. Panico,
- M. J. Sánchez,
- V. Benetou,
- R. Turzanski-Fortner,
- V. Katzke,
- A. Idahl,
- G. Skeie,
- K. Standahl Olsen,
- A. Tjønneland,
- J. Halkjaer,
- S. Colorado-Yohar,
- A. K. Heath,
- E. Sonestedt,
- H. Sartor,
- M. B. Schulze,
- D. Palli,
- M. Crous-Bou,
- A. Dorronsoro,
- K. Overvad,
- A. Barricarte Gurrea,
- G. Severi,
- R. C.H. Vermeulen,
- T. M. Sandanger,
- R. C. Travis,
- T. Key,
- P. Amiano,
- B. Van Guelpen,
- M. Johansson,
- M. Sund,
- R. Tumino,
- N. Wareham,
- C. Sacerdote,
- V. Krogh,
- P. Brennan,
- E. Riboli,
- E. Weiderpass,
- M. J. Gunter,
- V. Chajès
Affiliations
- S. G. Yammine
- Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS) , Nutritional Epidemiology Research Team (EREN), F-93017
- I. Huybrechts
- International Agency for Research on Cancer, World Health Organization
- C. Biessy
- International Agency for Research on Cancer, World Health Organization
- L. Dossus
- International Agency for Research on Cancer, World Health Organization
- S. Panico
- Dipartimento di medicina clinica e chirurgia, Federico II University
- M. J. Sánchez
- Escuela Andaluza de Salud Pública (EASP)
- V. Benetou
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens
- R. Turzanski-Fortner
- The German Cancer Research Center (DKFZ)
- V. Katzke
- The German Cancer Research Center (DKFZ)
- A. Idahl
- Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University
- G. Skeie
- Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway
- K. Standahl Olsen
- Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway
- A. Tjønneland
- Danish Cancer Society Research Center
- J. Halkjaer
- Danish Cancer Society Research Center
- S. Colorado-Yohar
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
- A. K. Heath
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College
- E. Sonestedt
- Department of Clinical Sciences Malmö
- H. Sartor
- Department of Clinical Sciences Malmö
- M. B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke
- D. Palli
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
- M. Crous-Bou
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat
- A. Dorronsoro
- Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa
- K. Overvad
- Department of Public Health, Aarhus University
- A. Barricarte Gurrea
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
- G. Severi
- Cancer Epidemiology Centre, Cancer Council Victoria
- R. C.H. Vermeulen
- Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht
- T. M. Sandanger
- Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway
- R. C. Travis
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford
- T. Key
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford
- P. Amiano
- Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa
- B. Van Guelpen
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- M. Johansson
- International Agency for Research on Cancer, World Health Organization
- M. Sund
- Department of Surgical and Perioperative Sciences, Umeå University
- R. Tumino
- Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7)
- N. Wareham
- MRC Epidemiology Unit, University of Cambridge
- C. Sacerdote
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital
- V. Krogh
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di
- P. Brennan
- International Agency for Research on Cancer, World Health Organization
- E. Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College
- E. Weiderpass
- International Agency for Research on Cancer, World Health Organization
- M. J. Gunter
- International Agency for Research on Cancer, World Health Organization
- V. Chajès
- International Agency for Research on Cancer, World Health Organization
- DOI
- https://doi.org/10.1186/s12885-023-10611-0
- Journal volume & issue
-
Vol. 23,
no. 1
pp. 1 – 12
Abstract
Abstract Background Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
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