Nature Communications (May 2024)
Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes
- Josh G. Chenoweth,
- Carlo Colantuoni,
- Deborah A. Striegel,
- Pavol Genzor,
- Joost Brandsma,
- Paul W. Blair,
- Subramaniam Krishnan,
- Elizabeth Chiyka,
- Mehran Fazli,
- Rittal Mehta,
- Michael Considine,
- Leslie Cope,
- Audrey C. Knight,
- Anissa Elayadi,
- Anne Fox,
- Ronna Hertzano,
- Andrew G. Letizia,
- Alex Owusu-Ofori,
- Isaac Boakye,
- Albert A. Aduboffour,
- Daniel Ansong,
- Eno Biney,
- George Oduro,
- Kevin L. Schully,
- Danielle V. Clark
Affiliations
- Josh G. Chenoweth
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Carlo Colantuoni
- Department of Neurology, Johns Hopkins School of Medicine
- Deborah A. Striegel
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Pavol Genzor
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Joost Brandsma
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Paul W. Blair
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Subramaniam Krishnan
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Elizabeth Chiyka
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Mehran Fazli
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Rittal Mehta
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Michael Considine
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Leslie Cope
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Audrey C. Knight
- Department of Neurology, Johns Hopkins School of Medicine
- Anissa Elayadi
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Anne Fox
- Naval Medical Research Unit EURAFCENT Ghana detachment
- Ronna Hertzano
- Section on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Andrew G. Letizia
- Naval Medical Research Unit EURAFCENT Ghana detachment
- Alex Owusu-Ofori
- Laboratory Services Directorate, Komfo Anokye Teaching Hospital (KATH)
- Isaac Boakye
- Research and Development Unit, KATH
- Albert A. Aduboffour
- Laboratory Services Directorate, Komfo Anokye Teaching Hospital (KATH)
- Daniel Ansong
- Child Health Directorate, KATH
- Eno Biney
- Accident and Emergency Department, KATH
- George Oduro
- Accident and Emergency Department, KATH
- Kevin L. Schully
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), Biological Defense Research Directorate, Naval Medical Research Command-Frederick
- Danielle V. Clark
- Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- DOI
- https://doi.org/10.1038/s41467-024-48821-0
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 13
Abstract
Abstract Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.
