Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior

Rasheen Powell; Violet A. Young; Kerri D. Pryce; Garrett D. Sheehan; Kwaku Bonsu; Abdulelah Ahmed; Arin Bhattacharjee

doi:10.1038/s41467-021-26100-6

Nature Communications (Oct 2021)

Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior

Rasheen Powell,
Violet A. Young,
Kerri D. Pryce,
Garrett D. Sheehan,
Kwaku Bonsu,
Abdulelah Ahmed,
Arin Bhattacharjee

Affiliations

Rasheen Powell: Pharmacology and Toxicology, University at Buffalo - The State University of New York
Violet A. Young: Program for Neuroscience, University at Buffalo - The State University of New York
Kerri D. Pryce: Pharmacology and Toxicology, University at Buffalo - The State University of New York
Garrett D. Sheehan: Program for Neuroscience, University at Buffalo - The State University of New York
Kwaku Bonsu: Pharmacology and Toxicology, University at Buffalo - The State University of New York
Abdulelah Ahmed: Pharmacology and Toxicology, University at Buffalo - The State University of New York
Arin Bhattacharjee: Pharmacology and Toxicology, University at Buffalo - The State University of New York

DOI: https://doi.org/10.1038/s41467-021-26100-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The authors show the endocytotic adaptor subunit called AP2A2 is differentially expressed in CGRP+ nociceptors. Locally inhibiting nociceptor endocytosis with a lipidated AP2 inhibitor peptide reduces acute and chronic pain-like behaviour in mice and rats, indicating prolonged analgesia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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