Investigating Prognostic Factors for Assisted Reproductive Technology Outcomes in Qadir-Mother and Child Hospital of Shiraz, Iran

Abstract

Background: Assisted reproductive technology (ART) helps infertility treatment. In this study, the researchers tried to find several prognostic factors for ART success. Methods: Data of 189 couples that had undergone ART at Qadir-Mother and Child hospital, were retrospectively explored. Cycles were classified as succeeded/failed and female/male/combined causes. Three classes of ovarian response based on the number of retrieved oocytes were determined. Duration of ovarian stimulation, dosages of gonadotropins, and sperm parameters were evaluated. Chi square, t-test and Pearson correlation were used for the analysis. Results: Couples with male factor infertility had a higher success rate. Female age had a negative correlation with follicle count (r = -0.25), retrieved oocytes (r = -0.25), fertilized oocytes (r= -0.2), and clinical pregnancy (r = -0.21). Female age was negatively correlated with AMH, although not significant. The fertilization rate had a reverse correlation with the basal FSH (r = -0.22, P= 0.01) and LH (r= -0.18, P= 0.05). Finally, ART success rate was positively correlated with the number of follicles before (r = 0.18, P = 0.05) and after retrieval (r = 0.15, P = 0.05) and fertilized oocyte (r = 0.23, P = 0.01). Conclusions: Female age, the number of mature follicles before retrieval, the number of retrieved oocyte, and fertilized oocytes are predictive factors in ART outcomes.

Keywords

• assisted reproductive technology
• infertility
• ovarian response