Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae

Agnieszka Tudek; Paweł S. Krawczyk; Seweryn Mroczek; Rafał Tomecki; Matti Turtola; Katarzyna Matylla-Kulińska; Torben Heick Jensen; Andrzej Dziembowski

doi:10.1038/s41467-021-25251-w

Nature Communications (Aug 2021)

Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae

Agnieszka Tudek,
Paweł S. Krawczyk,
Seweryn Mroczek,
Rafał Tomecki,
Matti Turtola,
Katarzyna Matylla-Kulińska,
Torben Heick Jensen,
Andrzej Dziembowski

Affiliations

Agnieszka Tudek: Institute of Biochemistry and Biophysics
Paweł S. Krawczyk: Institute of Biochemistry and Biophysics
Seweryn Mroczek: Laboratory of RNA Biology, International Institute of Molecular and Cell Biology
Rafał Tomecki: Institute of Biochemistry and Biophysics
Matti Turtola: Department of Molecular Biology and Genetics, Aarhus University
Katarzyna Matylla-Kulińska: Laboratory of RNA Biology, International Institute of Molecular and Cell Biology
Torben Heick Jensen: Department of Molecular Biology and Genetics, Aarhus University
Andrzej Dziembowski: Institute of Biochemistry and Biophysics

DOI: https://doi.org/10.1038/s41467-021-25251-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

RNA polyadenosine tails are important for the export, translation and stability of mRNAs and play a role in non-coding RNA biogenesis. Here the authors measure yeast poly(A) tail lengths by direct RNA sequencing, revealing its dynamics in yeast exonuclease, deadenylase and poly(A) polymerase mutants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal