Heat Shock Proteins (HSPs): a Review

Abstract

Heat shock proteins (HSPs) are a large class of proteins that have been conserved throughout evolution and exist by prokaryote and eukaryote organisms. Heat shock proteins play an important role in protein homeostasis. They can found in all major cellular compartments. The HSP90 family are important in the formation of the steroid receptor complex. The HSP70 family is necessary for protein synthesis, translocation, and folding. HSP60 family is important in protein stability. Many factors, e. g. heavy metals and organic toxic substances, elevated temperature in all cells responsive to the formation of proteins called stress proteins. This is happening with a simple bacterium and with complex of neurons too. The concentration of HSPs in muscle in young and adults birds is increasing rapidly in the cellular stress. Increasing HSPs leads to significant changes in gene expression, which lead to reconstruction of skeletal muscle.

Keywords

• chaperone
• expression
• stress
• high shock protein