Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis; Yasaman Alaghband; Enikö A. Kramár; Alberto J. López; Annie Vogel Ciernia; André O. White; Guanhua Shu; Diane Rhee; Christina M. Michael; Emilie Montellier; Yu Liu; Christophe N. Magnan; Siwei Chen; Paolo Sassone-Corsi; Pierre Baldi; Dina P. Matheos; Marcelo A. Wood

doi:10.1038/s41467-018-05868-0

Nature Communications (Aug 2018)

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis,
Yasaman Alaghband,
Enikö A. Kramár,
Alberto J. López,
Annie Vogel Ciernia,
André O. White,
Guanhua Shu,
Diane Rhee,
Christina M. Michael,
Emilie Montellier,
Yu Liu,
Christophe N. Magnan,
Siwei Chen,
Paolo Sassone-Corsi,
Pierre Baldi,
Dina P. Matheos,
Marcelo A. Wood

Affiliations

Janine L. Kwapis: Department of Neurobiology and Behavior, University of California
Yasaman Alaghband: Department of Neurobiology and Behavior, University of California
Enikö A. Kramár: Department of Neurobiology and Behavior, University of California
Alberto J. López: Department of Neurobiology and Behavior, University of California
Annie Vogel Ciernia: Department of Medical Microbiology and Immunology, University of California
André O. White: Department of Biological Sciences, Mount Holyoke College
Guanhua Shu: Department of Neurobiology and Behavior, University of California
Diane Rhee: Department of Neurobiology and Behavior, University of California
Christina M. Michael: Department of Neurobiology and Behavior, University of California
Emilie Montellier: Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California
Yu Liu: Department of Computer Science, University of California
Christophe N. Magnan: Department of Computer Science, University of California
Siwei Chen: Department of Computer Science, University of California
Paolo Sassone-Corsi: Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California
Pierre Baldi: Department of Computer Science, University of California
Dina P. Matheos: Department of Neurobiology and Behavior, University of California
Marcelo A. Wood: Department of Neurobiology and Behavior, University of California

DOI: https://doi.org/10.1038/s41467-018-05868-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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