Comparative Cytotoxic Assessment of Hydro-Methanolic Extracts Derived from Ripe <i>Morinda citrifolia</i> L. Fruit (Fresh, Dried, Pasteurized Juice) and Dried Seeds on Eukaryotic Normal and Carcinogenic Cellular Models

Abstract

Noni (Morinda citrifolia L.) is utilized for wellness drinks, puree, and nutraceuticals, while its seeds are a source of vegetable oil. However, misconceptions persist due to limited scientific research in Sri Lanka. This study evaluated the cytotoxic effects of hydro-methanolic extracts from fresh and dried noni fruits, pasteurized juice, and seeds on normal (BHK) and cancer (Hep2) cells using the MTT assay. The results indicated dose-dependent toxicity on cancer cells, while normal cells were less affected. Processing methods influenced cytotoxicity, with dried seeds showing the least toxicity. These findings suggest the potential of noni extracts as cytotoxic agents against cancer, influenced by the processing conditions. Further research is needed to identify the specific bioactive compounds and their mechanisms.

Keywords

• Noni (<i>Morinda citrifolia</i> L.)
• cytotoxicity
• nutraceuticals