Stereospecific ligands and their complexes, Part VIII: Antimicrobial activity of palladium(II) complexes with 0,0'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid

Abstract

Palladium(II) complexes (1-4) of general formula [PdCl2(R2-S,S-eddp)] with bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) were prepared and characterized by microanalysis, infrared and UV/VIS spectroscopy. The ligands and its complexes were tested for their in vitro antimicrobial activity against 15 species of bacteria and fungi. Testing is performed by the microdilution method, with the minimum inhibitory concentration (MIC) and the minimum microbicidal concentration (MMC) being determined. The MIC values were in range from 4.9 μg cm-3 to > 5000 μg cm-3 while MMC values ranged from 78 μg cm-3 to > 5000 μg cm-3. Palladium(II) complexes [PdCl2(Ln)] (n = 1-4) have statistically significant higher activity than the corresponding ligands. The complex 4 displayed the strongest activity among all tested compounds.

Keywords

• palladium(II) complexes
• antimicrobial activity
• electronic absorption spectra