Metal-Free Oxidative Dimerization of Dithiocarbamates: Direct Access to 3,5-Bis-mercapto-1,2,4-thiadiazoles

Abstract

Abstract A facile and efficient protocol for the synthesis of 3,5-bis-mercapto-1,2,4-thiadiazoles by the oxidative dimerization of S-alkyl dithiocarbamates using periodic acid as an inexpensive and commercially available oxidant is reported. High to excellent yields and short reaction times are the main advantages of this procedure.

Keywords

• 3,5-bismercaptoorganyl-1,2,4-thiadiazoles
• dithiocarbamate
• oxidative dimerization
• hypervalent iodine
• transition-metal-free