Communications Biology (Apr 2022)
The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart
Abstract
An in vitro assay in isolated heart mitochondria reveals that O-GlcNAcase inhibitor NButGT rapidly increases protein O-GlcNAcylation leading to increased respiratory capacity and complex I activity and decreased ROS release.