Frontiers in Oncology (May 2015)

Clinical impact of the immunome in lymphoid malignancies: the role of Myeloid-Derived Suppressor Cells

  • Calogero eVetro,
  • ALESSANDRA eROMANO,
  • Flavia eAncora,
  • Francesco eCoppolino,
  • Maria V Brundo,
  • Salvatore A Raccuia,
  • Salvatore A Raccuia,
  • Fabrizio ePuglisi,
  • Tibullo eDaniele,
  • Piera eLa Cava,
  • Cesarina eGiallongo,
  • Nunziatina L Parrinello

DOI
https://doi.org/10.3389/fonc.2015.00104
Journal volume & issue
Vol. 5

Abstract

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The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of myeloid-derived suppressor cells in the settings of lymphoid malignancies.

Keywords