Nature Communications (Nov 2019)
Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
- Julia Benkert,
- Simon Hess,
- Shoumik Roy,
- Dayne Beccano-Kelly,
- Nicole Wiederspohn,
- Johanna Duda,
- Carsten Simons,
- Komal Patil,
- Aisylu Gaifullina,
- Nadja Mannal,
- Elena Dragicevic,
- Desirée Spaich,
- Sonja Müller,
- Julia Nemeth,
- Helene Hollmann,
- Nora Deuter,
- Yassine Mousba,
- Christian Kubisch,
- Christina Poetschke,
- Joerg Striessnig,
- Olaf Pongs,
- Toni Schneider,
- Richard Wade-Martins,
- Sandip Patel,
- Rosanna Parlato,
- Tobias Frank,
- Peter Kloppenburg,
- Birgit Liss
Affiliations
- Julia Benkert
- Institute of Applied Physiology, University of Ulm
- Simon Hess
- Institute for Zoology, Biocenter, CECAD, University of Cologne
- Shoumik Roy
- Institute of Applied Physiology, University of Ulm
- Dayne Beccano-Kelly
- Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford
- Nicole Wiederspohn
- Institute of Applied Physiology, University of Ulm
- Johanna Duda
- Institute of Applied Physiology, University of Ulm
- Carsten Simons
- Institute of Applied Physiology, University of Ulm
- Komal Patil
- Institute of Applied Physiology, University of Ulm
- Aisylu Gaifullina
- Institute of Applied Physiology, University of Ulm
- Nadja Mannal
- Institute of Applied Physiology, University of Ulm
- Elena Dragicevic
- Institute of Applied Physiology, University of Ulm
- Desirée Spaich
- Institute of Applied Physiology, University of Ulm
- Sonja Müller
- Institute of Applied Physiology, University of Ulm
- Julia Nemeth
- Institute of Applied Physiology, University of Ulm
- Helene Hollmann
- Institute of Applied Physiology, University of Ulm
- Nora Deuter
- Institute of Applied Physiology, University of Ulm
- Yassine Mousba
- Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford
- Christian Kubisch
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf
- Christina Poetschke
- Institute of Applied Physiology, University of Ulm
- Joerg Striessnig
- Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences, University of Innsbruck
- Olaf Pongs
- Institute of Physiology, CIPMM, University of the Saarland
- Toni Schneider
- Institute for Neurophysiology, University of Cologne
- Richard Wade-Martins
- Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford
- Sandip Patel
- Department of Cell and Developmental Biology, UCL
- Rosanna Parlato
- Institute of Applied Physiology, University of Ulm
- Tobias Frank
- Department of Neurology, University Medicine Göttingen
- Peter Kloppenburg
- Institute for Zoology, Biocenter, CECAD, University of Cologne
- Birgit Liss
- Institute of Applied Physiology, University of Ulm
- DOI
- https://doi.org/10.1038/s41467-019-12834-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkinson’s disease, in contrast to the neuroprotective action of the neuronal Ca2+ sensor NCS-1.
