PLoS ONE (Jan 2021)

Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.

  • Yuya Fujita,
  • Toru Yago,
  • Tomoyuki Asano,
  • Haruki Matsumoto,
  • Naoki Matsuoka,
  • Jumpei Temmoku,
  • Shuzo Sato,
  • Makiko Yashiro-Furuya,
  • Eiji Suzuki,
  • Hiroshi Watanabe,
  • Atsushi Kawakami,
  • Kiyoshi Migita

DOI
https://doi.org/10.1371/journal.pone.0255493
Journal volume & issue
Vol. 16, no. 8
p. e0255493

Abstract

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BackgroundAdult-onset Still's disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cellular stress and has been identified as a DAMP that triggers the inflammatory response. The aim of this study is to investigate the clinical significance of serum CIRP levels in AOSD.MethodsSerum samples were obtained from 44 patients with active AOSD or 50 patients with rheumatoid arthritis (RA), 20 patients with systemic lupus erythematosus (SLE), and 15 healthy control patients (HCs). Serum levels of CIRP and IL-18 were determined using enzyme-linked immunosorbent assay. Results were compared among AOSD patients, RA patients, SLE patients and HCs. Results were also analyzed according to the clinical features of AOSD.ResultsSerum CIRP levels were significantly higher in AOSD patients compared with RA patients (median: 9.6 ng/mL, IQR [5.7-14.4] versus 3.2 ng/mL, IQR [1.9-3.8]; p ConclusionsThese results suggest that CIRP may play a significant role in the pathophysiology of AOSD and could be a potential biomarker for monitoring the disease activity of AOSD.