The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Lavanya Moparthi; Viktor Sinica; Vamsi K. Moparthi; Mohamed Kreir; Thibaut Vignane; Milos R. Filipovic; Viktorie Vlachova; Peter M. Zygmunt

doi:10.1038/s41467-022-33876-8

Nature Communications (Oct 2022)

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Lavanya Moparthi,
Viktor Sinica,
Vamsi K. Moparthi,
Mohamed Kreir,
Thibaut Vignane,
Milos R. Filipovic,
Viktorie Vlachova,
Peter M. Zygmunt

Affiliations

Lavanya Moparthi: Wallenberg Centre for Molecular Medicine, Linköping University
Viktor Sinica: Department of Cellular Neurophysiology, Institute of Physiology of the Czech Academy of Sciences
Vamsi K. Moparthi: Department of Physics, Chemistry, and Biology, Division of Chemistry, Linköping University
Mohamed Kreir: Janssen Research & Development, Division of Janssen Pharmaceutica N.V.
Thibaut Vignane: Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.
Milos R. Filipovic: Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.
Viktorie Vlachova: Department of Cellular Neurophysiology, Institute of Physiology of the Czech Academy of Sciences
Peter M. Zygmunt: Department of Clinical Sciences Malmö, Lund University

DOI: https://doi.org/10.1038/s41467-022-33876-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

The authors report how the cold and heat sensing properties of the pain receptor TRPA1 are separately modulated by the C-terminal intracellular domain, and in concert with either the S1–S4 or the S5–S6 transmembrane domain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal