Nature Communications (Nov 2020)

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

  • Kaushik Bhattacharya,
  • Lorenz Weidenauer,
  • Tania Morán Luengo,
  • Ellis C. Pieters,
  • Pablo C. Echeverría,
  • Lilia Bernasconi,
  • Diana Wider,
  • Yashar Sadian,
  • Margreet B. Koopman,
  • Matthieu Villemin,
  • Christoph Bauer,
  • Stefan G. D. Rüdiger,
  • Manfredo Quadroni,
  • Didier Picard

DOI
https://doi.org/10.1038/s41467-020-19783-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21

Abstract

Read online

Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance between protein folding and degradation.