Nature Communications (Dec 2017)

A modular synthesis of tetracyclic meroterpenoid antibiotics

  • Raphael Wildermuth,
  • Klaus Speck,
  • Franz-Lucas Haut,
  • Peter Mayer,
  • Bianka Karge,
  • Mark Brönstrup,
  • Thomas Magauer

DOI
https://doi.org/10.1038/s41467-017-02061-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Polycyclic meroterpenoids show a wide range of biological activities. Here, the authors report a modular approach to synthesize a number of natural and non-natural tetracyclic meroterpenoids, which display antibiotic activity against methicillin-resistant Staphylococcus aureus.