Nature Communications (Aug 2021)
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
- Seungyong Lee,
- Charles Hwang,
- Simone Marini,
- Robert J. Tower,
- Qizhi Qin,
- Stefano Negri,
- Chase A. Pagani,
- Yuxiao Sun,
- David M. Stepien,
- Michael Sorkin,
- Carrie A. Kubiak,
- Noelle D. Visser,
- Carolyn A. Meyers,
- Yiyun Wang,
- Husain A. Rasheed,
- Jiajia Xu,
- Sarah Miller,
- Amanda K. Huber,
- Liliana Minichiello,
- Paul S. Cederna,
- Stephen W. P. Kemp,
- Thomas L. Clemens,
- Aaron W. James,
- Benjamin Levi
Affiliations
- Seungyong Lee
- Department of Pathology, Johns Hopkins University
- Charles Hwang
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Simone Marini
- Department of Epidemiology, University of Florida
- Robert J. Tower
- Department of Orthopaedics, Johns Hopkins University
- Qizhi Qin
- Department of Pathology, Johns Hopkins University
- Stefano Negri
- Department of Pathology, Johns Hopkins University
- Chase A. Pagani
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Yuxiao Sun
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- David M. Stepien
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Michael Sorkin
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Carrie A. Kubiak
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Noelle D. Visser
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Carolyn A. Meyers
- Department of Pathology, Johns Hopkins University
- Yiyun Wang
- Department of Pathology, Johns Hopkins University
- Husain A. Rasheed
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Jiajia Xu
- Department of Pathology, Johns Hopkins University
- Sarah Miller
- Department of Pathology, Johns Hopkins University
- Amanda K. Huber
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Liliana Minichiello
- Department of Pharmacology, Oxford University
- Paul S. Cederna
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Stephen W. P. Kemp
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- Thomas L. Clemens
- Department of Orthopaedics, Johns Hopkins University
- Aaron W. James
- Department of Pathology, Johns Hopkins University
- Benjamin Levi
- Department of Surgery, Center for Organogenesis and Trauma, University of Texas
- DOI
- https://doi.org/10.1038/s41467-021-25143-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.
