Nature Communications (Sep 2016)
The myosin X motor is optimized for movement on actin bundles
- Virginie Ropars,
- Zhaohui Yang,
- Tatiana Isabet,
- Florian Blanc,
- Kaifeng Zhou,
- Tianming Lin,
- Xiaoyan Liu,
- Pascale Hissier,
- Frédéric Samazan,
- Béatrice Amigues,
- Eric D. Yang,
- Hyokeun Park,
- Olena Pylypenko,
- Marco Cecchini,
- Charles V. Sindelar,
- H. Lee Sweeney,
- Anne Houdusse
Affiliations
- Virginie Ropars
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Zhaohui Yang
- Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida College of Medicine
- Tatiana Isabet
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Florian Blanc
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Kaifeng Zhou
- Department of Molecular Biophysics and Biochemistry, Yale University
- Tianming Lin
- Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida College of Medicine
- Xiaoyan Liu
- Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida College of Medicine
- Pascale Hissier
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Frédéric Samazan
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Béatrice Amigues
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Eric D. Yang
- Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida College of Medicine
- Hyokeun Park
- Department of Physics, Division of Life Science, and State Key Laboratory of Molecular Neuroscience. The Hong Kong University of Science and Technology
- Olena Pylypenko
- Structural Motility, Institut Curie, PSL Research University, CNRS
- Marco Cecchini
- Laboratoire d'Ingénierie des Fonctions Moléculaires (ISIS), UMR 7006 CNRS, Université de Strasbourg
- Charles V. Sindelar
- Department of Molecular Biophysics and Biochemistry, Yale University
- H. Lee Sweeney
- Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida College of Medicine
- Anne Houdusse
- Structural Motility, Institut Curie, PSL Research University, CNRS
- DOI
- https://doi.org/10.1038/ncomms12456
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Myosin X is a molecular motor unique in its ability to generate filopodia, but the mechanism explaining this behaviour is not known. Here, through a combination of structure, single-molecule assays and modelling the authors show that myosin X is optimized for transport along actin bundles.
