Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

Abstract

Iminoester hydrochlorides 1 have been synthesized. These compounds werethen converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new seriesof substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared.Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3with isatin. The structures of all the new synthesized compounds were confirmed byelemental analyses, IR, 1H-NMR and 13C-NMR spectra.

Keywords

• Iminoesters
• ethoxycarbonyl hydrazones
• 4-amino-1
• 2
• 4-triazole-5-ones
• isatin