Selective biliary occlusion in rodents: description of a new technique

Abstract

Modern therapy concepts are of limited success in patients with cholestasis (e.g., biliary occluding malignancies). Therefore, we established a new animal model enabling simultaneous investigation of liver regeneration and hepato-biliary remodelling in biliary obstructed and biliary non-obstructed liver lobes.

Keywords

• cholestasis research
• experimental surgery
• hepatobiliary remodelling
• selective biliary transection