Synthesis and Inhibition of Influenza H1N1 Virus by Indolo-Glycyrrhetic Acid Cyanoesters

Anastasiya V. Petrova; Svetlana V. Belyaevskaya; Vladimir V. Zarubaev

doi:10.3390/M1475

Molbank (Oct 2022)

Synthesis and Inhibition of Influenza H1N1 Virus by Indolo-Glycyrrhetic Acid Cyanoesters

Anastasiya V. Petrova,
Svetlana V. Belyaevskaya,
Vladimir V. Zarubaev

Affiliations

Anastasiya V. Petrova: Ufa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Sciences, 71, Prospect Octyabrya, 450054 Ufa, Russia
Svetlana V. Belyaevskaya: Experimental Virology Laboratory, Department of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197001 St. Petersburg, Russia
Vladimir V. Zarubaev: Experimental Virology Laboratory, Department of Virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, 14 Mira St., 197001 St. Petersburg, Russia

DOI: https://doi.org/10.3390/M1475
Journal volume & issue: Vol. 2022, no. 4
p. M1475

Abstract

Read online

Two new indolo-glycyrrhetic acid derivatives containing cyano-substitutent at C30 have been synthesized, and their anti-influenza activity has been evaluated in vitro. The resulting data demonstrated moderate inhibitory activity against the H1N1 virus with IC50 29 and 23 μM, respectively. The value of SI 18 and 21 confirm low toxicity and potential of new compounds for following research and development of new biological agents.

Published in Molbank

ISSN: 1422-8599 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry
Website: https://www.mdpi.com/journal/molbank

About the journal

Abstract

Keywords