Nature Communications (Jun 2017)
MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis
- Mariola Kurowska-Stolarska,
- Stefano Alivernini,
- Emma Garcia Melchor,
- Aziza Elmesmari,
- Barbara Tolusso,
- Clare Tange,
- Luca Petricca,
- Derek S. Gilchrist,
- Gabriele Di Sante,
- Chantal Keijzer,
- Lynn Stewart,
- Clara Di Mario,
- Vicky Morrison,
- James M. Brewer,
- Duncan Porter,
- Simon Milling,
- Ronald D. Baxter,
- David McCarey,
- Elisa Gremese,
- Greg Lemke,
- Gianfranco Ferraccioli,
- Charles McSharry,
- Iain B. McInnes
Affiliations
- Mariola Kurowska-Stolarska
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Stefano Alivernini
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Emma Garcia Melchor
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Aziza Elmesmari
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Barbara Tolusso
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Clare Tange
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Luca Petricca
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Derek S. Gilchrist
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Gabriele Di Sante
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Chantal Keijzer
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Lynn Stewart
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Clara Di Mario
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Vicky Morrison
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- James M. Brewer
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Duncan Porter
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Simon Milling
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Ronald D. Baxter
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- David McCarey
- NHS Greater Glasgow and Clyde
- Elisa Gremese
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Greg Lemke
- Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
- Gianfranco Ferraccioli
- Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart
- Charles McSharry
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Iain B. McInnes
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- DOI
- https://doi.org/10.1038/ncomms15877
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.
