Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome

Marina Reixachs-Solé; Jorge Ruiz-Orera; M. Mar Albà; Eduardo Eyras

doi:10.1038/s41467-020-15634-w

Nature Communications (Apr 2020)

Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome

Marina Reixachs-Solé,
Jorge Ruiz-Orera,
M. Mar Albà,
Eduardo Eyras

Affiliations

Marina Reixachs-Solé: The John Curtin School of Medical Research, Australian National University
Jorge Ruiz-Orera: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
M. Mar Albà: IMIM - Hospital del Mar Medical Research Institute
Eduardo Eyras: The John Curtin School of Medical Research, Australian National University

DOI: https://doi.org/10.1038/s41467-020-15634-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are translated.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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