Quantitative Distribution of Cerebral Venous Oxygen Saturation and Its Prognostic Value in Patients with Acute Ischemic Stroke

Fengqiu Cao; Mingming Wang; Shanhua Han; Shengyu Fan; Yingwei Guo; Yingjian Yang; Yu Luo; Jia Guo; Yan Kang

doi:10.3390/brainsci12081109

Brain Sciences (Aug 2022)

Quantitative Distribution of Cerebral Venous Oxygen Saturation and Its Prognostic Value in Patients with Acute Ischemic Stroke

Fengqiu Cao,
Mingming Wang,
Shanhua Han,
Shengyu Fan,
Yingwei Guo,
Yingjian Yang,
Yu Luo,
Jia Guo,
Yan Kang

Affiliations

Fengqiu Cao: College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China
Mingming Wang: Department of Radiology, School of Medicine, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai 200434, China
Shanhua Han: Department of Radiology, School of Medicine, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai 200434, China
Shengyu Fan: College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China
Yingwei Guo: College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China
Yingjian Yang: College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China
Yu Luo: Department of Radiology, School of Medicine, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai 200434, China
Jia Guo: Department of Psychiatry, Columbia University, New York, NY 10027, USA
Yan Kang: College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China

DOI: https://doi.org/10.3390/brainsci12081109
Journal volume & issue: Vol. 12, no. 8
p. 1109

Abstract

Read online

This study investigated the quantitative distribution of cerebral venous oxygen saturation (SvO2) based on quantitative sensitivity mapping (QSM) and determined its prognostic value in patients with acute ischemic stroke (AIS). A retrospective study was conducted on 39 hospitalized patients. Reconstructed QSM was used to calculate the cerebral SvO2 of each region of interest (ROI) in the ischemic hemisphere. The intraclass correlation coefficient (ICC) and Bland–Altman analysis were conducted to define the best resolution of the distribution map. The correlation between the cerebral SvO2 in hypoxic regions (SvO2ROI 3 and asymmetrically prominent cortical veins regions (ICC: 0.879 (admission), ICC: 0.906 (discharge)). The cerebral SvO2 was significantly negative with clinical scores (all |r| > 0.3). The cerebral SvO2 and its changes at discharge were significantly associated with an unfavorable prognosis (OR: 0.812 and 0.866). Therefore, the cerebral SvO2 in hypoxic regions measured by the quantitative distribution map can be used as an indicator for evaluating the early prognosis of AIS.

Published in Brain Sciences

ISSN: 2076-3425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.mdpi.com/journal/brainsci/

About the journal

Abstract

Keywords