APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection

Ping An; Efe Sezgin; Gregory D. Kirk; Priya Duggal; Elizabeth Binns-Roemer; George Nelson; Sophie Limou; Mark L. Van Natta; Douglas A. Jabs; Michelle Estrella; Jeffrey B. Kopp; Cheryl A. Winkler

doi:10.1038/s42003-021-01812-z

Communications Biology (Mar 2021)

APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection

Ping An,
Efe Sezgin,
Gregory D. Kirk,
Priya Duggal,
Elizabeth Binns-Roemer,
George Nelson,
Sophie Limou,
Mark L. Van Natta,
Douglas A. Jabs,
Michelle Estrella,
Jeffrey B. Kopp,
Cheryl A. Winkler

Affiliations

Ping An: Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research
Efe Sezgin: Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research
Gregory D. Kirk: Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health
Priya Duggal: Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health
Elizabeth Binns-Roemer: Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research
George Nelson: Center for Cancer Research Informatics Core, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
Sophie Limou: Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research
Mark L. Van Natta: Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health
Douglas A. Jabs: Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health
Michelle Estrella: Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco
Jeffrey B. Kopp: Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Cheryl A. Winkler: Basic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research

DOI: https://doi.org/10.1038/s42003-021-01812-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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An et al. determine the presence of variants of the innate immune factor APOL1 in four cohorts of HIV-positive patients. The study suggests that APOL1 might confer carriers of two variant alleles protection from HIV related opportunistic infections, especially fungal infections.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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