Role of Ihh — a progesterone-responsive gene in mammalian reproduction: a review

Abstract

Abstract Indian hedgehog (Ihh) is a member of the developmentally regulated morphogens, the hedgehog gene family. The Hh protein family was initially discovered in Drosophila and has since been widely investigated in both Drosophila and higher animals. Ihh exhibited a dynamic spatiotemporal expression pattern in the mammalian uterus and ovaries. The downstream targets of the Ihh signaling pathway include PTCH-1, SMO, and COUP-TFII. Ihh is a progesterone-responsive gene that plays an important function in the female reproductive system; conditional ablation results in infertility due to failed embryo implantation. The literature addressing Ihh’s functions and ways of action is expanding, as is the number of processes that use it in cell signaling as well as physiology. Even while our grasp of the path has expanded tremendously, we still have many gaps in our knowledge. This review will address the discovery, evolution, mechanisms, and manifestations of Ihh especially in mammalian reproduction.

Keywords

• Ihh
• Progesterone-responsive gene
• Discovery
• Downstream targets
• Significant role