Nature Communications (Aug 2019)
EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
- Zhixiong Sun,
- Xiguang Xu,
- Jianlin He,
- Alexander Murray,
- Ming-an Sun,
- Xiaoran Wei,
- Xia Wang,
- Emmarose McCoig,
- Evan Xie,
- Xi Jiang,
- Liwu Li,
- Jinsong Zhu,
- Jianjun Chen,
- Alexei Morozov,
- Alicia M. Pickrell,
- Michelle H. Theus,
- Hehuang Xie
Affiliations
- Zhixiong Sun
- Fralin Life Sciences Institute at Virginia Tech
- Xiguang Xu
- Fralin Life Sciences Institute at Virginia Tech
- Jianlin He
- Fralin Life Sciences Institute at Virginia Tech
- Alexander Murray
- Fralin Life Sciences Institute at Virginia Tech
- Ming-an Sun
- Fralin Life Sciences Institute at Virginia Tech
- Xiaoran Wei
- Fralin Life Sciences Institute at Virginia Tech
- Xia Wang
- Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine
- Emmarose McCoig
- Fralin Life Sciences Institute at Virginia Tech
- Evan Xie
- Fralin Life Sciences Institute at Virginia Tech
- Xi Jiang
- Department of Pharmacology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Liwu Li
- Department of Biological Sciences, Virginia Tech
- Jinsong Zhu
- Department of Biochemistry, Virginia Tech
- Jianjun Chen
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Alexei Morozov
- Department of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine
- Alicia M. Pickrell
- School of Neuroscience, Virginia Tech
- Michelle H. Theus
- Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine
- Hehuang Xie
- Fralin Life Sciences Institute at Virginia Tech
- DOI
- https://doi.org/10.1038/s41467-019-11905-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
It is unclear why neuronal activity induced methylation changes are limited to specific loci in the genome. Here, authors show that the DNA demethylation enzyme, TET1, gains its specificity via the interaction with EGR1, a sequence specific DNA binding protein.
