Characterisation of a nucleo-adhesome

Adam Byron; Billie G. C. Griffith; Ana Herrero; Alexander E. P. Loftus; Emma S. Koeleman; Linda Kogerman; John C. Dawson; Niamh McGivern; Jayne Culley; Graeme R. Grimes; Bryan Serrels; Alex von Kriegsheim; Valerie G. Brunton; Margaret C. Frame

doi:10.1038/s41467-022-30556-5

Nature Communications (Jun 2022)

Characterisation of a nucleo-adhesome

Adam Byron,
Billie G. C. Griffith,
Ana Herrero,
Alexander E. P. Loftus,
Emma S. Koeleman,
Linda Kogerman,
John C. Dawson,
Niamh McGivern,
Jayne Culley,
Graeme R. Grimes,
Bryan Serrels,
Alex von Kriegsheim,
Valerie G. Brunton,
Margaret C. Frame

Affiliations

Adam Byron: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Billie G. C. Griffith: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Ana Herrero: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Alexander E. P. Loftus: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Emma S. Koeleman: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Linda Kogerman: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
John C. Dawson: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Niamh McGivern: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Jayne Culley: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Graeme R. Grimes: MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
Bryan Serrels: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Alex von Kriegsheim: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Valerie G. Brunton: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
Margaret C. Frame: Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh

DOI: https://doi.org/10.1038/s41467-022-30556-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesion proteins can cooperate to control transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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