Study of postvaccinal immunity to whooping cough in children with connective tissue dyslasia syndrome

Abstract

Purpose: to evaluate the effectiveness of post-vaccination immunity against whooping cough in children aged 1 to 17 years with connective tissue dysplasia syndrome in Stavropol.The principal component analysis was used to optimize the interpretation of immunograms in connective tissue dysplasia syndromedepending on protective titers for whooping cough. Analysis by the method of principal components showed that the links of cellular immunity predominate in children with connective tissue dysplasia syndrome with low titers of antibodies to whooping cough.The general variant of the response of the immune system was observed in children with protective titers of antibodies to whooping cough (1: 160—1: 320). In children with connective tissue dysplasia with titres of 1: 640or more antibodies to whooping cough, humoral and cellular immunities are closely interrelated, it is the presence of humoral and cellular immunity that makesit possible to develop a stable immunity to preventable infections.Thus, the method of main components effectively provides accessible information on key immune processes and is promising.

Keywords

• connective tissue dysplasia
• cellular and humoral immunity
• pertussis
• whooping cough
• intensity immunity