Frontiers in Psychiatry (Dec 2021)
Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis
- Lindsay M. Melhuish Beaupre,
- Lindsay M. Melhuish Beaupre,
- Arun K. Tiwari,
- Arun K. Tiwari,
- Vanessa F. Gonçalves,
- Vanessa F. Gonçalves,
- Vanessa F. Gonçalves,
- Clement C. Zai,
- Clement C. Zai,
- Clement C. Zai,
- Clement C. Zai,
- Victoria S. Marshe,
- Victoria S. Marshe,
- Cathryn M. Lewis,
- Cathryn M. Lewis,
- Nicholas G. Martin,
- Andrew M. McIntosh,
- Mark J. Adams,
- Bernhard T. Baune,
- Bernhard T. Baune,
- Bernhard T. Baune,
- Doug F. Levinson,
- Dorret I. Boomsma,
- Brenda W. J. H. Penninx,
- Gerome Breen,
- Gerome Breen,
- Steve Hamilton,
- Swapnil Awasthi,
- Stephan Ripke,
- Stephan Ripke,
- Stephan Ripke,
- Stephan Ripke,
- Lisa Jones,
- Ian Jones,
- Enda M. Byrne,
- Ian B. Hickie,
- James P. Potash,
- Jianxin Shi,
- Myrna M. Weissman,
- Myrna M. Weissman,
- Yuri Milaneschi,
- Stanley I. Shyn,
- Eco J. C. de Geus,
- Gonneke Willemsen,
- Gregory M. Brown,
- Gregory M. Brown,
- James L. Kennedy,
- James L. Kennedy,
- James L. Kennedy,
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Affiliations
- Lindsay M. Melhuish Beaupre
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Lindsay M. Melhuish Beaupre
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Arun K. Tiwari
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Arun K. Tiwari
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Vanessa F. Gonçalves
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Vanessa F. Gonçalves
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Vanessa F. Gonçalves
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Clement C. Zai
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Clement C. Zai
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Clement C. Zai
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Clement C. Zai
- Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
- Victoria S. Marshe
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Victoria S. Marshe
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- Cathryn M. Lewis
- Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom
- Cathryn M. Lewis
- Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
- Nicholas G. Martin
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
- Andrew M. McIntosh
- Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- Mark J. Adams
- Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- Bernhard T. Baune
- Department of Psychiatry, University of Münster, Münster, Germany
- Bernhard T. Baune
- 0Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia
- Bernhard T. Baune
- 1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia
- Doug F. Levinson
- 2Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States
- Dorret I. Boomsma
- 3Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, Netherlands
- Brenda W. J. H. Penninx
- 4Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands
- Gerome Breen
- Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom
- Gerome Breen
- 5National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, King's College London, London, United Kingdom
- Steve Hamilton
- 6The Permanente Medical Group, San Francisco, CA, United States
- Swapnil Awasthi
- 7Department of Psychiatry and Psychotherapy, Universitäts Medizin Berlin Campus Charité Mitte, Berlin, Germany
- Stephan Ripke
- 7Department of Psychiatry and Psychotherapy, Universitäts Medizin Berlin Campus Charité Mitte, Berlin, Germany
- Stephan Ripke
- 8Analytic and Translational Genetic Unit, Massachusetts General Hospital, Boston, MA, United States
- Stephan Ripke
- 9Medical and Population Genetics, Broad Institute, Cambridge, MA, United States
- Stephan Ripke
- 0Department of Psychiatry, Charité, Berlin, Germany
- Lisa Jones
- 1Psychological Medicine, University of Worcester, Worcester, United Kingdom
- Ian Jones
- 2Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom
- Enda M. Byrne
- 3Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
- Ian B. Hickie
- 4Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia
- James P. Potash
- 5Psychiatry Department, University of Iowa, Iowa City, IA, United States
- Jianxin Shi
- 6Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
- Myrna M. Weissman
- 7Psychiatry Department, Columbia University College of Physicians and Surgeons, New York, NY, United States
- Myrna M. Weissman
- 8Division of Epidemiology, New York State Psychiatric Institute, New York, NY, United States
- Yuri Milaneschi
- 4Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands
- Stanley I. Shyn
- 9Washington Permanente Medical Group, Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States
- Eco J. C. de Geus
- 4Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands
- Gonneke Willemsen
- 4Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands
- Gregory M. Brown
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- Gregory M. Brown
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- James L. Kennedy
- Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
- James L. Kennedy
- Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
- James L. Kennedy
- Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
- DOI
- https://doi.org/10.3389/fpsyt.2021.734077
- Journal volume & issue
-
Vol. 12
Abstract
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many promising hits for genetics of insomnia in a population-based sample.Methods: Using data from the largest available GWAS of insomnia and other sleep traits, we sought to test if sleep variable PRS scores derived from population-based studies predicted sleep variables in samples of depressed cases [Psychiatric Genomics Consortium - Major Depressive Disorder subjects (PGC MDD)]. A leave-one-out analysis was performed to determine the effects that each individual study had on our results.Results: The only significant finding was for insomnia, where p-value threshold, p = 0.05 was associated with insomnia in our PGC MDD sample (R2 = 1.75−3, p = 0.006).Conclusion: Our results reveal that <1% of variance is explained by the variants that cover the two significant p-value thresholds, which is in line with the fact that depression and insomnia are both polygenic disorders. To the best of our knowledge, this is the first study to investigate genetic overlap between the general population and a depression sample for insomnia, which has important treatment implications, such as leading to novel drug targets in future research efforts.
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