Associations of endocrine disrupting chemicals with renal function in older individuals

Jiaoyang Chen; Yue Wang; Zhixin Zhao; Ye Deng; Tianyun Wang; Yuting Xiang; Yuting Wang; Jiamei Chen; Miao He

Hygiene and Environmental Health Advances (Sep 2024)

Associations of endocrine disrupting chemicals with renal function in older individuals

Jiaoyang Chen,
Yue Wang,
Zhixin Zhao,
Ye Deng,
Tianyun Wang,
Yuting Xiang,
Yuting Wang,
Jiamei Chen,
Miao He

Affiliations

Jiaoyang Chen: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Yue Wang: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Zhixin Zhao: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Ye Deng: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Tianyun Wang: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Yuting Xiang: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Yuting Wang: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Jiamei Chen: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China
Miao He: Liaoning Key Laboratory of Environmental Health Damage Research and Assessment, Department of Environmental Health, School of Public Health, China Medical University, Shenyang, 110122, China; Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, China; Corresponding author.

Journal volume & issue: Vol. 11
p. 100098

Abstract

Read online

Background: Since the twentieth century, endocrine-disrupting substances (EDCs) such as phthalates and organophosphates have been utilised in various goods. The long-term usage of these products may have negative effects on people's health. Most EDCs are metabolized through kidneys, but there are few research investigating renal damage from exposure to EDCs in the elderly. This study aims to examine the effects of EDCs exposure on renal function in the elderly population. Methods: In this cross-sectional study, a total of 200 elder from a community in northeast China were enrolled. All subjects were investigated by questionnaire, physical examination, and biological sample collection. Estimated glomerular filtration rate (eGFR) was used to classify renal function group. Lasso regression was used to screen out the EDCs related to renal function. After covariate adjustment, binary logistic regression was used to analyze the relationship between decreased renal function and EDCs. Weighted quantile sum (WQS) regression was used to assess the association of combined-EDCs with decreased renal function, subgroup analyses were performed to identify potentially sensitive populations to the effects of EDCs on decreased renal function. Results: Binary logistic regression showed that 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-COOH), Mono(3-carboxypropyl) phthalate (MCPP), and Methyl paraben (MeP) were negatively associated with decreased renal function, with odds ratio (OR) and 95% confidence intervals of 0.591 (0.366, 0.954), 0.990 (0.981, 0.999) and 0.997 (0.995, 0.999), respectively. WQS regression found DPP (Weights = 22.5%) to have the greatest effect on decreased renal function in the elderly. Moreover, significant potential interactions were observed among MEHP&MOcP with hypertension on decreased renal function (Pinteraction = 0.014), as well as BPS and MEHP&MocP with Overweight/obesity on decreased renal function (Pinteraction = 0.032, 0.024). Conclusions: BHT-COOH, MCPP, and MeP were negatively associated with decreased renal function in the elderly. Elders with hypertension and who are overweight /obesity may be more sensitive to EDCs.

Published in Hygiene and Environmental Health Advances

ISSN: 2773-0492 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Public aspects of medicine; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.sciencedirect.com/journal/hygiene-and-environmental-health-advances

About the journal

Abstract

Keywords